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KMID : 0359020020250010007
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Korean Journal of Gastrointestinal Endoscopy
2002 Volume.25 No. 1 p.7 ~ p.12
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The Question of Difference in cagA and vacA Subtypes of Helicobacter plylori among Chronic Gastritis, Duodenal Ulcer, and Gastric Adenocarcinoma
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Kim Jin-Il
Kim Sung-Soo
Choi Gyu-Yong
Chung In-Sik
Han Joon-Yeol
Chung Kyu-Won
Sun Hee-Sik
Kim Jae-Kwang
Park Soo-Heon
Han Sok-Won
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Abstract
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Background/Aims: Approximately 80% of Korean adults are infected with Helicobacter pylori. Although H.pylori is associated with the chronic gastritis, peptic ulcer, and gastric adenocarcinoma, only a small number of infected patients
develop these conditions. Therefore, there may be more virulent disease-specific sbutypes of H.pylori in patients with gastroduldenal disease. To investigate the disease-specific subtypes of cagA and vacA in Korea, evaluation was made on these subtypes of H.pylori.
Methods: Twenty two patients with chronic gastritis, 21 patietns with duodenal ulcer, and 23 patients with gastric adenocarcinoma were examined. All patietns underwent endoscopic biopsy. H.pylori was cultured and genomic DNA was
extracted. PCR-base cagA and vacA were subtyped and vacuolating cytotoxin was assayed using HeLa cells.
Results: The presence of cagA was observed in 95.5%, 100%, and 95.7%, the vacA sla subype was detected in 100%, 90.5%, and 95.7%, the vacA mlb subtype was detecte in 95.5%, 90.5%, and 95.7% in chronic gastritis, duodenal ulcer, and gastric adenocarcinoma, respectively.
Conclusions: The H.pylori with cagA and subtype sla/mlb vacA gene was predomnant regardless of the type of gastroduodenal disease. There were on difference in the cagA and vacA subytepes of H.pylori among the chronic gastritis, duodenal ulcer, and gastric adenocarcinoma in Korea.
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KEYWORD
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Helicobacter pylori, cagA, vacA, Helicobacter pylori, cagA, vacA,
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